PublishedPapers
2025
Functionally divergent melanocortin receptor subtypes and the HPI axis in sea lamprey
Shaughnessy CA, Myhre VD, McCormick SD, Dores RM
A Cftr-independent, Ano1-rich seawater-adaptive ionocyte in sea lamprey gills
Shaughnessy CA, Hall DJ, Norstog JL, Ferreira-Martins D, Barany A, Regish AM, Breves JP, Komoroske LM, McCormick SD
Physiological and morphological traits affect contemporary range expansion and implications for species distribution modeling in an amphibian species
Edwards OM, Reichert MS, Ozmen L, Shaughnessy CA, Zhai L, Zhang B
2024
Salinity and prolactin regulate anoctamin 1 in the model teleost, Fundulus heteroclitus
Breves JP, Posada M, Tao Y, Shaughnessy CA
Endocrine control of gill ionocyte function in euryhaline fishes
Breves JP, Shaughnessy CA
Ion Regulation in Anadromous Fishes
Shaughnessy CA, Bystriansky JS
2023
Functional characterization of melanocortin 2 receptor (Mc2r) from a lobe-finned fish (Protopterus annectens) and insights into the molecular evolution of melanocortin receptors
Shaughnessy CA, Le K, Myhre VD, Dores RM
Molecular and pharmacological analysis of the melanocortin-2 receptor and its accessory proteins Mrap1 and Mrap2 in a Squalomorph shark, the Pacific spiny dogfish
Bouyoucos IA, Shaughnessy CA, Anderson WG, Dores RM.
Hypothalamus-pituitary-interrenal (HPI) axis signaling in Atlantic sturgeon (Acipenser oxyrinchus) and sterlet (Acipenser ruthenus)
Shaughnessy CA, Myhre VD, Hall DJ, McCormick SD, Dores RM
Trends in the evolution of the elasmobranch melanocortin-2 receptor: insights from structure/function studies on the activation of whale shark Mc2r
Hoglin BE, Miner MV, Erdenebayar U, Shaughnessy CA, Dores RM
Juvenile sea lamprey (Petromyzon marinus) have a wide window of elevated salinity tolerance that is eventually limited during springtime warming
Shaughnessy CA, McCormick SD
2022
Structure/function studies on the activation motif of two non-mammalian Mrap1 orthologs, and observations on the phylogeny of Mrap1, including a novel characterization of an Mrap1 from the chondrostean fish, Polyodon spathula
Dores RM, McKinley G, Meyers A, Martin M, Shaughnessy CA
Human melanocortin-2 receptor: identifying a role for residues in the TM4, EC2, and TM5 domains in activation and trafficking as a result of co-expression with the accessory protein, Mrap1 in Chinese hamster ovary cells
Davis PV, Shaughnessy CA, Dores RM
A basal actinopterygian melanocortin receptor: molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus)
Shaughnessy CA, Jensen MF, Dores RM
IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function
Kotas ME, Moore C, Gurrola II JG, Pletcher S, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang I, Li Y, Montgomery MT, Lee K, Cope E, Locksley RM, Seibold MA, Gordon ED
The isosmotic point as critical salinity limit for growth and osmoregulation, but not survival, in the wolf eel Anarrhichthys ocellatus
Shaughnessy CA, Balfry SK, Bystriansky JS
Net benefit of ivacaftor during prolonged tezacaftor/elexacaftor exposure in vitro
Shaughnessy CA, Zeitlin PL, Bratcher PE
Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway
Shaughnessy CA, Yadav S, Bratcher PE, Zeitlin PL
2021
Tissue and salinity specific Na+/Cl- cotransporter (NCC) orthologues involved in the adaptive osmoregulation of sea lamprey (Petromyzon marinus)
Barany A, Shaughnessy CA, Pelis RM, Fuentes J, Mancera JM, McCormick SD
Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment
Shaughnessy CA, Zeitlin PL, Bratcher PE
11-Deoxycortisol is a stress responsive and gluconeogenic hormone in a jawless vertebrate, the sea lamprey (Petromyzon marinus)
Shaughnessy CA, McCormick SD
Corticosteroid control of Na+/K+-ATPase in the intestine of the sea lamprey (Petromyzon marinus)
Barany A*, Shaughnessy CA*, McCormick SD
Down-regulation of the epithelial sodium channel (ENaC) in human airway epithelia in response to low temperature incubation
Yadav S*, Shaughnessy CA*, Zeitlin PL, Bratcher PE
Molecular mechanisms of Cl- transport in fishes: new insights and their evolutionary context
Shaughnessy CA, Breves JP
2020
Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings
Bratcher PE, Yadav S, Shaughnessy CA, Thornell IM, Zeitlin PL
11-Deoxycortisol controls hydromineral balance in the most basal osmoregulating vertebrate, sea lamprey (Petromyzon marinus)
Shaughnessy CA, Barany A, McCormick SD
Osmoregulatory role of the intestine in the sea lamprey (Petromyzon marinus)
Barany A, Shaughnessy CA, Fuentes J, Mancera JM, McCormick SD
Functional characterization and osmoregulatory role of gill Na+/K+/2Cl- cotransporter (NKCC1) in sea lamprey (Petromyzon marinus), a basal vertebrate
Shaughnessy CA, McCormick SD
Upper thermal tolerance and heat shock protein response of juvenile American shad (Alosa sapidissima)
Bayse S*, Shaughnessy CA*, Regish A, McCormick SD
2018
Reduced thermal tolerance during salinity acclimation in brook trout (Salvelinus fontinalis) can be rescued by prior treatment with cortisol
Shaughnessy CA, McCormick SD
2017
Survival and osmoregulation of the purple marsh crab (Sesarma reticulatum) at varying salinity and pH
Shaughnessy CA, Anderson EC, Kasparian M, LaMontagne JM, Bystriansky JS
2015
Interaction of osmoregulatory and acid-base compensation in white sturgeon (Acipenser transmontanus) during exposure to aquatic hypercarbia and elevated salinity
Shaughnessy CA, Baker DW, Brauner CJ, Morgan JD, Bystriansky JS